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Nucleosides and Nucleotides Volume 18, 1999 - Issue 6-7
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OLIGONUCLEOTIDES I. PROGRESS IN THE SYNTHESIS, BUILDING BLOCKS, AND HYDROLYTIC PROPERTIES

Chemoselective Synthesis of Dithymidine Phosphorothioate in Solution Using O-Protected Thiophosphate Monomers

Thomas Boesen Department of Chemistry, University of Copenhagen, The H. C. Ørsted Institute, Universitetsparken 5, DK-2100, Copenhagen, Denmark
,
Jan Kehler Department of Chemistry, University of Copenhagen, The H. C. Ørsted Institute, Universitetsparken 5, DK-2100, Copenhagen, Denmark
&
Otto Dahl Department of Chemistry, University of Copenhagen, The H. C. Ørsted Institute, Universitetsparken 5, DK-2100, Copenhagen, Denmark
Pages 1241-1242 | Published online: 04 Oct 2006
 
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Abstract

Diastereomerically pure O-protected thymine monothioate nucleotide (I) is efficiently coupled to protected thymidine (II) in a chemoselective, but not stereoselective manner, to give dithymidine phosphorothioates (III).

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