The Role of the Epigenome in Gene Expression Control and the Epimark Changes in Response to the Environment

Abstract

Our knowledge base involving the biochemical participants of epigenetic control has expanded greatly over the last decade. The role of epigenetic marks to DNA and histones controlled by non-coding RNAs is one of the most intensely studied areas of biology today. This review covers many of the mechanisms that non-coding RNAs and other molecules use to control gene expression and eventually affect responses to the environment. In the first part of the review, we discuss the array of covalent modifications to the genome that constitute the epigenome, which consists of the histone variants, covalent modifications, and post-translational modifications that result in gene expression changes. How the histone variants and post-translational modifications including, acetylation, methylation, phosphorylation, ubiquitination and sumoylation help form the epigenome is also summarized. Our eventual understanding of how the environment controls these modifications will open incredible opportunities in agriculture, medicine and the development of practical tools for biology. In the second part of this review we discuss the growing list of environmentally-mediated epigenetic modifications, and examples of transgenerational epigenetic inheritance events, that may begin to change our views of adaptive responses to the environment and evolution.

Keywords:

• Abiotic stress
• arabidopsis
• environnment
• epigenetic
• epigenome epimarks

ACKNOWLEDGMENTS

The work has been generously supported by time and facilities provided by the WCU program, Gyeongsang National University, Republic of Korea. We apologize to the authors of many important uncited works for which space was limited even in this very extensive document. We thank the numerous colleagues who provided invaluable advice and debate, Rebekah Fagan and Patricia Hunter Bressan for help and unlimited patience in the manuscript preparation.