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Cancer Investigation Volume 26, 2008 - Issue 2
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ORIGINAL ARTICLE Preclinical Therapeutics

TAE226 Inhibits Human Neuroblastoma Cell Survival

Elizabeth A. Beierle Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida, USA
,
Angelica Trujillo Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida, USA
,
Abhilasha Nagaram H. Lee Moffit Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA
,
Vita M. Golubovskaya Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida, USA
,
William G. Cance Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida, USA
&
Elena V. Kurenova Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida, USA
Pages 145-151 | Published online: 11 Jun 2009
 
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Abstract

Purpose. Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro. Materials and Methods. Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated. Results. Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis. Conclusions. Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.

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