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Cancer Investigation Volume 26, 2008 - Issue 4
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ORIGINAL ARTICLE Cellular and Molecular Biology

Paradoxical Expression of Anti-Apoptotic and MRP Genes on Cancer Stem-Like Cell Isolated from TJ905 Glioblastoma Multiforme Cell Line

Feng Jin Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Lei Zhao Department of Hepatology and Infections Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Hong-Yang Zhao Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Shou-Gang Guo Department of Neurology, Shandong Provincial Hospital, Jinan, People's Republic of China
,
Jun Feng Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Xiao-Bing Jiang Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Shu-Ling Zhang Department of Hepatology and Infections Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Yu-Jia Wei Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
,
Rong Fu Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
&
Jia-Shan Zhao Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
 show all
Pages 338-343 | Published online: 11 Jun 2009
 
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Abstract

Existence of cancer stem cell is regarded as a main reason for metastasis and/or recurrences. In this study, the cancer stem-like cell derived from TJ905 glioblastoma multiforme cell line was isolated successfully. However, it was observed that generating rate of the cancer stem-like cells was lower than that of TJ905 cells, that expression of the anti-apoptotic and multidrug resistance-associated protein (MRP) genes were paradoxical to the literatures, which showed the uncertainty of cancer stem cells, and that some stem cell was not the solo factor to maintain tumor growth and resist apoptosis and anti-tumor drugs.

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