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Cancer Investigation Volume 26, 2008 - Issue 4
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ORIGINAL ARTICLE Cellular and Molecular Biology

FKBP51 Expressed by Both Normal Epithelial Cells and Adenocarcinoma of Colon Suppresses Proliferation of Colorectal Adenocarcinoma

Hiromi Mukaide First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Yasushi Adachi First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan; Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Shigeru Taketani Department of Biotechnology, Kyoto Institute of Technology, Sakyo-ku, Kyoto, Japan
,
Masayoshi Iwasaki First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Naoko Koike-Kiriyama First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Akio Shigematsu First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Ming Shi First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Seiji Yanai First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Kazuhiko Yoshioka Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan
,
Yasuo Kamiyama Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan; Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan
&
Susumu Ikehara First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan; Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
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Pages 385-390 | Published online: 11 Jun 2009
 
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Abstract

It has been reported, as a result of Western blot analyses, that FKBP51 is expressed in various tissues, but that it is not expressed in the pancreas, lung, colon, stomach, or spleen. In this paper, we show, using Western blot analyses, reverse transcriptase polymerase chain reaction, and immunohistochemical analyses of samples from colon cancer patients, that both normal epithelial cells and adenocarcinoma in the human colon express FKBP51, and that there are no significant differences in the expressions of FKBP51 between them. We also show that FKBP51 suppresses the proliferation of colorectal adenocarcinoma, possibly due to the suppression of functions of the glucocorticoid receptors.

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