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Cancer Investigation Volume 26, 2008 - Issue 9
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ORIGINAL ARTICLESClinical Translational Therapeutics

Rituximab-Induced Severe Acute Thrombocytopenia: A case Report and Review of Literature

Suneel Dhand Franklin Square Hospital Center, Baltimore, Maryland, USA
&
Huzefa Bahrain Franklin Square Hospital Center, Baltimore, Maryland, USA
Pages 913-915 | Published online: 11 Jun 2009
 
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Abstract

Rituximab, an anti-CD20 monoclonal antibody, is generally a safe and well-tolerated drug. Severe acute thrombocytopenia following administration of rituximab is a rare phenomenon, with few previously reported cases in the literature. We report a case of an 84-year old male with a diagnosis of mantle cell lymphoma who suffered severe acute thrombocytopenia following rituximab infusion. A literature review of the previously published cases is also presented.

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