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Cancer Investigation Volume 27, 2009 - Issue 1
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ORIGINAL ARTICLES Clinical Translational Therapeutics

Low expression of Foxo3a is Associated with Poor Prognosis in Ovarian Cancer Patients

Min Fei Institute of Medical Biotechnology, Soochow University, Suzhou, China
,
Yueming Zhao Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Yuchan Wang Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Mudan Lu Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Chun Cheng Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Xiaodong Huang Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Dongmei Zhang Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Jianxin Lu Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
,
Song He Department of Pthology, Affiliated Cancer Hospital of Nantong University, Medical College of Nantong University, Nantong, China
&
Aiguo Shen The Jiangsu Province Key Lab of Neuroregeneration, Nantong University, Nantong, China
 show all
Pages 52-59 | Published online: 11 Jun 2009
 
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Abstract

To investigate whether Foxo3a expression is correlated with p27kip1 protein levels as well as how it might be clinically relevant, we evaluated the expression of Foxo3a in several ovarian tumors. Immunohistochemical analysis was performed in 63 cases of ovarian tumors. Ten cases were evaluated by Western blot analysis. There was a correlation observed between Foxo3a over-expression and clinic pathological parameters (p = 0.032). Kaplan-Meier survival analysis showed that Foxo3a low expression was significantly associated with poor prognosis of patients. It may be a useful prognostic marker and target in ovarian cancer.

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