Advanced search
Publication Cover
Cancer Investigation Volume 27, 2009 - Issue 2
Submit an article Journal homepage
291
Views
40
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLES Clinical Translational Therapeutics

YY1 Over-Expression in Human Brain Gliomas and Meningiomas Correlates with TGF-β1, IGF-1 and FGF-2 mRNA Levels

Stavroula Baritaki Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California, USA
,
Anthoula M. Chatzinikola Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece
,
Antonios F. Vakis Department of Neurosurgery, University Hospital of Crete, Heraklion, Crete, Greece
,
Nikolaos Soulitzis Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece
,
Dimitris A. Karabetsos Department of Neurosurgery, University Hospital of Crete, Heraklion, Crete, Greece
,
Ioannis Neonakis Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece
,
Benjamin Bonavida Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California, USA
&
Demetrios A. Spandidos Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece
 show all
Pages 184-192 | Published online: 11 Jun 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

In this study we examined by QRT-PCR the mRNA expression of TGF-β 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors. Our findings introduce YY1, for the first time, as a novel gene implicated in brain gliomatogenesis and meningioma establishment. We present a positive correlation between the autocrine expression of YY1 and TGF-β 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.