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Cancer Investigation Volume 27, 2009 - Issue 1
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ORIGINAL ARTICLES Clinical Translational Therapeutics

Metastatic Breast Cancer: Overall Survival Related to Successive Chemotherapies. What Do We Gain After the Third Line?

Olivier Tacca Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France; EA 4231, Clermont-Ferrand Cédex 1, France
,
Marianne LeHeurteur Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France
,
Xavier Durando Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France
,
Marie-Ange Mouret-Reynier Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France
,
Catherine Abrial Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France; EA 4231, Clermont-Ferrand Cédex 1, France
,
Emilie Thivat Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France; EA 4231, Clermont-Ferrand Cédex 1, France
,
Mathilde Bayet-Robert Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France; EA 4231, Clermont-Ferrand Cédex 1, France
,
Frederique Penault-Llorca Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France; EA 4231, Clermont-Ferrand Cédex 1, France; Université d'Auvergne, Clermont-Ferrand Cédex 1, France
&
Phillippe Chollet Bureau de Recherche Clinique, Centre Jean Perrin, Clermont-Ferrand Cédex 1, France; EA 4231, Clermont-Ferrand Cédex 1, France; Université d'Auvergne, Clermont-Ferrand Cédex 1, France; Centre d'Investigation Clinique, Clermont-Ferrand Cédex 1, France
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Pages 81-85 | Published online: 11 Jun 2009
 
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Abstract

This retrospective study analyzed, in metastatic breast cancer (MBC), overall survival (OS) related to each subsequent line of chemotherapy (CT). We evaluated 578 patients with a MBC. Among these patients, 558 patients were stratified according to the number of differents CT lines received. Median OS decreased from 22.5 to 12.3 months. Nevertheless, survival was rather stable for subsequent lines after the third line of CT around 8 months. In our study, it appeared useful to give several CT lines when possible. Subsequent lines of CT could have a beneficial effect on the survival for some patients with MBC.

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