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Cancer Investigation Volume 27, 2009 - Issue 4
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ORIGINAL ARTICLES Clinical Translational Therapeutics

Upregulation of GRP78 and GRP94 and Its Function in Chemotherapy Resistance to VP-16 in Human Lung Cancer Cell Line SK-MES-1

Lichuan Zhang Department of Respiratory Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China; Dalian Medical University, Dalian, China
,
Siyan Wang Dalian Medical University, Dalian, China
,
Wangtao Department of Respiratory Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
,
Yanyan Wang Dalian Medical University, Dalian, China
,
Jiarui Wang Dalian Medical University, Dalian, China
,
Li Jiang Dalian Medical University, Dalian, China
,
Sheng Li Dalian Medical University, Dalian, China
,
Xiujuan Hu Department of Respiratory Medicine, Thorax Hospital of Tianjin, Tianjin, China
&
Qi Wang Department of Respiratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
 show all
Pages 453-458 | Published online: 20 Jul 2009
 
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Abstract

The upregulation of GRP78 and GRP94 under the induction of A23187 and its function in drug resistance to etoposide (VP-16) was investigated in human lung cancer cell line SK-MES-1. The expression of GRP78 and GRP94 induced by A23187 at different concentrations was analyzed by RT-PCR and Western blotting. Cell survival to VP-16 was determined using a colony-formation assay. The expression of GRP78 and GRP94 in the cells was found to correspond well with the cell survival to VP-16. The results showed that upregulation of GRP78 and GRP94 can significantly confer the chemoresistance to VP-16 in human lung cancer cell line SK-MES-1.

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