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Cancer Investigation Volume 27, 2009 - Issue 5
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ORIGINAL ARTICLES Clinical Translational Therapeutics

Aberrant DNA Methylation in Thymic Epithelial Tumors

Chen Chen Department of Cardiothoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Bangliang Yin Department of Cardiothoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Qiyou Wei Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Daiqiang Li Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Jianguo Hu Department of Cardiothoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Fenglei Yu Department of Cardiothoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
&
Qianjin Lu Epigenetic Research Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
 show all
Pages 582-591 | Published online: 20 Jul 2009
 
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Abstract

Aberrant DNA methylation plays a critical role in the development and progression of many types of cancer. To investigate whether DNA methylation is abnormal in thymic epithelial tumors (TETs), we analyzed global methylation levels and the methylation status of 9 tumor suppressor gene (TSG) promoters in 65 TET samples. We found evidence of TSG promoter hypermethylation and decreased TSG expression in severe TETs. Furthermore, relative to early-stage TETs, global DNA methylation levels were reduced and DNA methyltransferase expression was increased in advanced-stage TETs. Our results suggest that aberrant DNA methylation is associated with TET development.

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