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Cancer Investigation Volume 28, 2010 - Issue 4
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ORIGINAL ARTICLEClinical Translational Therapeutics

Prognostic Value of the t(14;18)(q32;q21) in Patients With Diffuse Large B-Cell Lymphoma

Hasan Abdel-GhaffarMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
,
Sherin Abd El-AzizMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
,
Doaa ShahinMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
,
Heba DegheidyMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
,
Tarek SelimMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
,
Ezzat ElsobkyMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
,
Nadia AttwanMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
&
Youssef A. Al-TonbaryMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt
 show all
Pages 376-380 | Published online: 22 Apr 2010
 
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ABSTRACT

The prognostic significance of the t(14;18) in diffuse large B-cell lymphoma is still controversial. To assess the impact of the t(14;18) on patient survival, we investigated 26 patients with diffuse large B-cell lymphoma for the presence of t(14;18). The t(14;18) was detected in 90.9% of patients with high international prognostic index score. The five-year overall survival was 0.0% and 68.75% in positive and negative cases of t(14;18) respectively. The detection of the t(14;18) combined with the international prognostic index score is a useful strategy for more appropriate risk stratification and prediction of outcome of patients with diffuse large B-cell lymphoma.

ACKNOWLEDGMENT

The authors thank Dr. Nadia Mokhtar, the head of the pathology department in the National Cancer Institute, for her kind care and her technicians workgroup.

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