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Cancer Investigation Volume 34, 2016 - Issue 6
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Original Articles

SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer

Qunwei WangMinimally Invasive Surgery Center, Central South University, Changsha, China
,
Zhu-lin YangResearch Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, ChinaCorrespondence[email protected]
,
Qiong ZouDepartment of Pathology, Third Xiangya Hospital, Central South University, Changsha, China
,
Yuan YuanDepartment of Pathology, Third Xiangya Hospital, Central South University, Changsha, China
,
Jinghe LiDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, China
,
Lufeng LiangDepartment of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People's Hospital, Changsha, China
,
Guixiang ZengDepartment of Pathology, Loudi Central Hospital, Loudi, China
&
Senlin ChenDepartment of Pathology, Hunan Provincial Tumor Hospital, Changsha, China
 show all
Pages 255-264 | Received 01 Apr 2015, Accepted 21 May 2016, Published online: 07 Jul 2016
 
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ABSTRACT

Biomarkers for the diagnosis, prognosis, and targeting therapy of gallbladder cancers are not clinically available. This study demonstrated that the percentage of cases with positive SHP2 and UGP2 expression significantly correlated with the percentage of cases with positive vimentin, β-catenin, MMP2, MMP9, and Ki-67 expression, large tumor size, high TNM stage, lymph node metastasis, and survival in patients with adenocarcinomas and squamous cell/adenosquamous carcinomas. Positive SHP2 and UGP2 expression are independent poor-prognostic factors in both types of tumors. Our study suggested that positive SHP2 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer.

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