Hypoxia: A Double-Edged Sword in Cancer Therapy

ABSTRACT

Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.

KEYWORDS:

• Hypoxia
• HIF-1
• Chemoresistance
• Radioresistance
• Hypoxia-targeted therapy

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.