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Cancer Investigation Volume 35, 2017 - Issue 4
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Articles

Novel Glycopyrrolidine Compounds Inhibit Human Cancer Cell Proliferation and Induce Apoptotic Mode of Cell Death

Hemadev BhoopalanDepartment of Human Genetics, Sri Ramachandra University, Porur, Chennai, India
,
Shilpa TentuDepartment of Biotechnology, Indian Institute of Technology Madras (IITM), Chennai, India
,
Prasana RDepartment of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India
,
Purushothaman SDepartment of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India
,
Akkanapally VenuDepartment of Human Genetics, Sri Ramachandra University, Porur, Chennai, India
,
Ragavachary RaghunathanDepartment of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India
,
Suresh Babu PakalaIndian Institute of Science Education & Research (IISER), Tirupati, India
,
Suresh Kumar RayalaDepartment of Biotechnology, Indian Institute of Technology Madras (IITM), Chennai, India
&
Ganesh VenkatramanDepartment of Human Genetics, Sri Ramachandra University, Porur, Chennai, IndiaCorrespondence[email protected] [email protected]
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Pages 215-224 | Received 06 Jun 2016, Accepted 09 Nov 2016, Published online: 16 Mar 2017
 
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ABSTRACT

Spirocyclic compounds, present in a number of bioactive natural alkaloids, are cyclic systems containing one carbon atom common to two rings. A highly regioselective glycopyrrolidine compound library was synthesized using 1,3-dipolar cycloaddition method, and its efficacy was tested on cell lines representing most commonly occurring cancers and the molecular mechanism of cell death deciphered. Results showed that among the 16 compounds screened, RPRR210 showed the most potent anticancer activity and induced cell cycle arrest, inhibited migration, caused cell death by inducing apoptosis through the intrinsic pathway, and were nontoxic to normal cells.

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