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Cancer Investigation Volume 35, 2017 - Issue 9
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Article

11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

Ciro FranzeseRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – ItalyCorrespondence[email protected]
,
Egesta LopciNuclear Medicine, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy
,
Lucia Di BrinaRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy
,
Giuseppe Roberto D'AgostinoRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy
,
Pierina NavarriaRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy
,
Pietro MancosuRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy
,
Stefano TomatisRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy
,
Arturo ChitiNuclear Medicine, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy;Humanitas University, Department of Biomedical Sciences, Via Manzoni 113 20089Rozzano (Milano) – Italy
&
Marta ScorsettiRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy;Humanitas University, Department of Biomedical Sciences, Via Manzoni 113 20089Rozzano (Milano) – Italy
 show all
Pages 586-593 | Received 04 Jan 2017, Accepted 30 Aug 2017, Published online: 05 Oct 2017
 
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ABSTRACT

Introduction: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.

Materials and methods: patients with 1 – 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.

Results: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).

Conclusion: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

Declaration of interest statement

The authors report no declarations of interest

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