MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR₂) -Promoted Cancer Cell Migration

ABSTRACT

Activation of proteinase-activated receptor 2 (PAR₂) promotes cell migration in cancers, but the exact mechanism underlying this process remains largely unknown. Here we report that activation of PAR₂ reduced miR-205 expression, whereas inhibition of miR-205 promoted cell migration in cancer cells. Overexpression of miR-205 blocked PAR₂-mediated stimulation of cell migration. BMPR1B was identified as a downstream target gene of miR-205. In colorectal carcinoma specimens from patients, the level of PAR₂ was negatively correlated with that of miR-205, but it was positively associated with BMPR1B expression. Taken together, our findings indicate that PAR₂ signaling promotes cancer cell migration through miR-205/BMPR1B pathway in human colorectal carcinoma.

KEYWORDS:

• PAR₂
• Migration
• miR-205
• BMPR1B
• Colorectal cancer

Conflict of interest

The authors declare that they have no conflicts of interest with the contents of this article.

Acknowledgement

This work was supported by funding from the National Nature Science Foundation of China (81472560), National Key research and development program of the Ministry of Science and Technology of China (2016YFC0905301) and CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-1-001).