MicroRNA-187 Inhibits Growth and Metastasis of Osteosarcoma by Downregulating S100A4

ABSTRACT

Abnormal expression and dysfunction of microRNAs are correlated with osteosarcoma (OS). This study demonstrated that the miR-187 level in OS tissues and cell lines was decreased. The proliferation and metastatic abilities of U-2OS cells were inhibited by miR-187 overexpression and promoted by miR-187 knockdown. Moreover, miR-187 also inhibited growth and metastasis of OS cells in vivo. Furthermore, we revealed that miR-187 could interact with S100A4 3′-UTR and inhibit S100A4 expression in OS cells. In summary, miR-187 inhibits growth and metastasis of OS cells by downregulating S100A4, which might be a potential biomarker and therapeutic target of OS.

KEYWORDS:

• miR-187
• Osteosarcoma
• S100A4
• Proliferation
• metastasis

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Funding

None to declare.