Potential Molecular Targets in the Treatment of Lung Cancer Using siRNA Technology

ABSTRACT

Lung cancer is the leading cause of cancer-related mortality with about 1.6 million deaths every year worldwide. Gene mutations and overexpression of oncogenes play a central role in malignant transformation in NSCLC. Conventional approaches for treatments of NSCLC have shown low levels of success while showing severe side effects. Target therapy using siRNA has recently emerged as a new strategy for cancer treatment by specific targeting of genes involved in the development and metastasis of cancer. This article dedicated to an update review of molecular targets could potentially be used for target therapy of lung cancer using SiRNA technology.

KEYWORDS:

• Target therapy
• Non-small-cell lung cancer
• siRNA
• KRAS
• EGFR

Additional information

Funding

Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Science. Tabriz, Iran [102895].