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Cancer Investigation Volume 36, 2018 - Issue 2
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Articles

Combination of Vaccine-Strain Measles and Mumps Viruses Enhances Oncolytic Activity against Human Solid Malignancies

Ho Anh SonDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi, VietnamView further author information
,
LiFeng ZhangDepartment of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;Department of immunology, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang autonomous region, ChinaView further author information
,
Bui Khac CuongDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi, VietnamView further author information
,
Hoang Van TongDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam;Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, VietnamView further author information
,
Le Duy CuongDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi, VietnamView further author information
,
Ngo Thu HangDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi, VietnamView further author information
,
Hoang Thi My NhungFaculty of Biology, VNU University of Science, Hanoi, VietnamView further author information
,
Naoki YamamotoDepartment of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeView further author information
&
Nguyen Linh ToanDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi, VietnamCorrespondence[email protected]
View further author information
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Pages 106-117 | Received 14 Jul 2017, Accepted 26 Jan 2018, Published online: 27 Feb 2018
 
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ABSTRACT

Oncolytic measles and mumps viruses (MeV, MuV) have a potential for anti-cancer treatment. We examined the anti-tumor activity of MeV, MuV, and MeV-MuV combination (MM) against human solid malignancies (HSM). MeV, MuV, and MM targeted and significantly killed various cancer cell lines of HSM but not normal cells. MM demonstrated a greater anti-tumor effect and prolonged survival in a human prostate cancer xenograft tumor model compared to MeV and MuV. MeV, MuV, and MM significantly induced the expression of immunogenic cell death markers and enhanced spleen-infiltrating immune cells. In conclusion, MM combination significantly improves the treatment of human solid malignancies.

Declaration of interest statement

All authors have no conflicts of interest to declare.

Additional information

Funding

This study was funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 106-YS.06-2013.22. NY was supported by grant number NUHSRO/2012/197/Hanoi/01.

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