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Cancer Investigation Volume 36, 2018 - Issue 7
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Original Articles

Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development

Ashten N. OmsteadEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Juliann E. KosovecEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Daisuke MatsuiDepartment of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan;
,
Samantha A. MartinEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Matthew A. SmithDepartment of Pathology and Laboratory Medicine, Allegheny Health Network, Pittsburgh, PA, USA;
,
D. Aaron GuelEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Jenna KolanoEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Yoshihiro KomatsuEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Fahim HabibEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Christopher LaiEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Kevi ChristopherEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA;
,
Ronan J. KellyDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA
,
Ali H. ZaidiEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA; Correspondence[email protected] [email protected]
&
Blair A. JobeEsophageal and Lung Institute, Allegheny Health Network, Pittsburgh, PA, USA; Correspondence[email protected] [email protected]
 show all
Pages 363-370 | Received 05 Dec 2017, Accepted 22 Jun 2018, Published online: 24 Aug 2018
 
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Abstract

A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression.

Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett’s with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.

Acknowledgments

Nothing to report.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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