The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer

Abstract

Prostate cancer (PCa) is the most common malignant tumor for men. But the mechanism is unclear. EIF3C was shown to be overexpressed in PCa tissues and cell lines. EIF3C overexpression was correlated to age and tumor stage in PCa patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Additionally, the phosphorylation level of PI3K and Akt was downregulated while total NF-κB and Myc decreased after EIF3C knockdown. But the expression of IκB increased reversely. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-κB signaling pathway in PC3 cells.

Keywords:

• EIF3C
• prostate cancer
• PI3K/Akt
• NF-κB

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Funding

The study was supported by Doctor’s foundation of Guizhou People’s Hospital and the Grant no. was GZSYBS[2015]017. This study was also supported by Project of Guizhou Science and Technology Department and the Grant no. was Basis of Guizhou-Family Cooperation [2019]1208.