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Cancer Investigation Volume 37, 2019 - Issue 7
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Articles

Elevation of Serum CEA in Patients with Squamous Cell Carcinoma of the Anus

Gabriel T. RaabDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA; View further author information
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Daniel S. O’NeilDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA; View further author information
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Ravi P. KiranDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA; ;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA; ;Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA; View further author information
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Daniel L. FeingoldHerbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA; ;Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA; View further author information
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Steven A. Lee-KongHerbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA; ;Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA; View further author information
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David P. HorowitzHerbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA; ;Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, New York, USAView further author information
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Alfred I. NeugutDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA; ;Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA; ;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Correspondence[email protected]
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Pages 288-292 | Received 15 May 2019, Accepted 22 Jun 2019, Published online: 18 Jul 2019
 
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Abstract

The proportion of anal cancer cases that produce elevated carcinoembryonic antigen (CEA) levels is not well described in the medical literature. In this study, we used electronic health record data from a single urban cancer center to identify patients from 2004–2018 with anal cancer who have also had a pre-initial treatment CEA measurement. We identified 40 patients who met our eligibility criteria. Of those, 11 (27.5%) had an elevated pretreatment CEA. Elevated CEA was not associated with any of the clinical or demographic covariates; however, three out of five patients with a recurrence had an elevated CEA.

Declaration of interest

Dr. Neugut has served as a consultant to Eisai, Otsuka, Hospira, and United Biosource Corporation. He is on the scientific advisory board of EHE, Intl. Dr. O’Neil has received an honorarium from Ipsen. No other authors have any conflicts of interest or disclosures.

Additional information

Funding

Dr. O’Neil was funded by a Conquer Cancer Foundation of American Society of Clinical Oncology Endowed Young Investigator Award in memory of Evelyn H. Lauder.

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