Upregulation of NUCKS1 in Lung Adenocarcinoma is Associated with a Poor Prognosis

Abstract

To evaluate the clinicopathologic features and survival analysis of NUCKS1 expression in human lung adenocarcinoma (LA), we used bioinformatic methods to obtain NUCKS1 gene status and correlated it with prognosis in LA. We compared NUCKS1 expression in 70 samples of LA with intrinsically normal lung alveoli (NLA) by immunohistochemistry, and analyzed their clinicopathologic features. NUCKS1 was overexpressed in LA components(LACs) relative to NLA, and was significantly correlated to patient with 5-year disease-free survival (DFS) and overall survival(OS). Elevated NUCKS1 expression in LACs was shown to be an independent prognostic indicator for OS and a biomarker in LA.

Keywords:

• NUCKS1
• immunohistochemistry
• lung adenocarcinoma
• clinicopathologic features

Acknowledgements

The authors wish to thank the technicians in the Pathology Department at Qingdao Central Hospital for preparing the slides, and Dr. Feng Hou for scanning the histologic slides.

Disclosure statement

The authors declare that they have no conflicts of interest.

Additional information

Funding

This study was supported by the Qingdao Medical Scientific Research Guidance Plan [grant no. 2019-WJZD076].