Abstract
Role of interleukin-10 (IL-10) promoter polymorphisms in the risk of oral cancer (OC) remains controversial. The present study aimed to explore the relation between IL10 promoter polymorphisms and the progression of oral cancer by performing meta-analysis. Seven studies with a total of 2141 controls and 1928 cases were included in our analysis. Overall results showed significant associations between IL-10-1082A/G gene polymorphism and OC susceptibility under all five models. However, OC was not significantly related to the IL-10-592A/C or −819 T/C polymorphism (p > 0.05).
Acknowledgements
The authors thank the School of Stomatology of China Medical University for technical support with this study.
Author contributions
R.L. carried out the idea and collected important background information. R.L. and L.L. performed the literature search, data extraction, and data analysis. R.L. and Z.Z. drafted the manuscript. Z.Z. revised the final manuscript. All writers read and approved the final manuscript.
Disclosure statement
The authors declare that they have no conflicts of interest.