277
Views
5
CrossRef citations to date
0
Altmetric
Review

Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment

, , , , &
Pages 627-644 | Received 10 Mar 2021, Accepted 04 Jul 2021, Published online: 19 Jul 2021
 

Abstract

Glioblastoma (GB) is the most lethal form of primary brain neoplasm. TMZ is the first-line standard treatment, but the strong resistance constrains the efficacy in clinical use. GB contains glioma stem cells (GSCs), which contribute to TMZ resistance, promote cell survival evolvement, and repopulate the tumor mass. This review summarizes the TMZ-resistance mechanisms and discusses several potential therapies from the conservative opinion of GSC-targeted therapy orientation to the current view of TMZ resistance-aimed efficacy, which will provide an understanding of the role of heterogeneity in drug resistance and improve therapeutic efficacy in general.

Acknowledgments

Thanks to YL, PZ, and DH for their critical review of this manuscript.

Author contributions

All authors reviewed and approved the final manuscript. LQL and LD contributed to the conception and design of the paper. LQL and SZL drafted the paper. SZL provided useful comments and suggestions. LD and LQL revised the paper.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Funding

This work was supported by grants from the Natural Science Foundation of Beijing Municipality (Z190018), The National Natural Science Foundation of China (81870123), and the National Science Foundation for Young Scientists of China (81902545). Thanks for the biological and medical engineering core facilitates of School of Life Science, Beijing Institute of Technology.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.