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Research Article

Nivolumab-Related Dry Mouth and Dry Eye: Cross-Sectional Study

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 797-807 | Received 09 Jan 2021, Accepted 16 Aug 2021, Published online: 22 Sep 2021
 

Abstract

To evaluate ICIs related dry eye and dry mouth in nivolumab therapy, 24 patients receiving nivolumab (group 1), 30 patients in remission without treatment for 6 months (group 2), 30 healthy participants (group 3) were cross-sectionally examined. Schirmer’s 1, 2, TSH blood tests, serological analysis, salivary flow scintigraphy and minor-salivary gland biopsy were performed. Schirmer’s tests were performed with anesthetic (1) and without anesthetic (2). Schirmer’s scores were lower in group 1 with more frequent reduced tear production (p < 0.001). TSH levels negatively correlated with Schirmer’s scores. Functional insufficiency was detected by salivary flow scintigraphy in 7 out of 10 patients with Schirmer’s test positivity. In Schirmer’s positive patients, lymphocytic sialadenitis was confirmed in 4 patients (focus score > 1) and CD4 T lymphocyte precipitation was observed in 6 patients. Nivolumab therapy may be associated with ICIs related immune sicca.

Acknowledgements

We are grateful to all participants and patients. There is no funding for this study.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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