224
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Surgical Trauma-induced CCL2 Upregulation Mediates Lung Cancer Progression by Promoting Treg Recruitment in Mice and Patients

, , , , , , , , & show all
Pages 91-102 | Received 25 Jun 2021, Accepted 01 Sep 2021, Published online: 27 Sep 2021
 

Abstract

Surgical removal of the tumor is currently the first-line treatment for lung cancer, but the procedure may accelerate cancer progression through immunosuppression. However, whether CCL2 (C-C motif chemokine ligand 2) enhances cancer progression by affecting regulatory T cells (Tregs) remains unknown. We found that the volume and weight of tumors were larger in the surgical trauma group than in the control group. CCL2 expression and Treg abundance were increased in tumor tissues after surgical trauma, and CCL2 expression was positively associated with Treg abundance. These results demonstrated that surgical trauma contributes to lung cancer progression by increasing CCL2 expression, thus promoting Treg recruitment.

Acknowledgments

The authors thank Hulun Li (Harbin Medical University, China) for providing skilled assistance with the flow cytometry apoptosis assay.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This study was funded by the 2019 Fundamental Research Funds for the Provincial Universities [grant no. 2019KYYWF-0356 to X.Z.], the 2021 Fundamental Research Funds for the Provincial Universities [to Xidong Zhu], the Heilongjiang Postdoctoral Foundation [grant no. LBH-Z19185 to X.Z.], the project funded by the China Postdoctoral Science Foundation [grant no. 2020M670924 to X.Z.] and Harbin Medical University Cancer Hospital Top Young Talent Project [grant no. BJQN 2020-03 to X.Z.].

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.