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Original Articles

Identification of a Novel Pyroptosis-Related Gene Signature for Predicting Prognosis in Bladder Cancer

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Pages 134-150 | Received 09 Sep 2021, Accepted 07 Oct 2021, Published online: 21 Oct 2021
 

Abstract

Bladder cancer (BC) has an unpredictable prognosis. Pyroptosis is a novel form of programmed cell death. However, whether the pyroptosis-related genes have a prognostic value remains unknown. In this study, we downloaded the mRNA expression and clinical data of BC patients and used the LASSO Cox analysis was employed to build a signature. High-risk patients had a significantly lower overall survival (OS) (p < .0001). Single-sample gene set enrichment analysis (ssGSEA) indicated that the tumor immune microenvironment was different between the two risk groups. In conclusion, a pyroptosis-related signature can be used for OS prediction of patients with BCs.

Acknowledgments

The authors thank AiMi Academic Services (www.aimieditor.com) for the English language editing and review services.

Disclosure statement

The authors declare no competing interests.

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