Metastasis to Breast from Extramammary Solid Tumors and Lymphomas: A 20-Year Population-Based Study

Abstract

To discuss the clinicopathological features and prognosis of metastases to the breast from extramammary solid tumors and lymphomas, we reviewed Cancer Hospital of Chinese Academy of Medical Sciences database from 01/01/2000 to 12/31/2020. Fifty-nine patients were identified. The most common primary sites for breast metastases were lymph node and pulmonary, followed by nasal cavity, ovary, skin, etc. All the patients were treated with chemotherapy, 18 were operated, 14 accepted radiotherapy. Metastasis to breast should be considered in any patient with tumor history presenting a breast lump. Pathological with immunohistochemical examination should be performed to identify the original site.

Keywords:

• Breast
• malignancies
• metastasis
• lymphoma
• extramammary tumors

Acknowledgments

The authors would like to thank our colleagues at the Department of Breast and Abdominal Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical and Peking Union Medical College.

Author contributions

Yihang Qi (Y. H. Q.) concepted and designed this study, and carried out the primary literature search, performed the data analysis, drafted the manuscript; Y. H. Q., Xiangyi Kong (X. Y. K.), Xiangyu Wang (X. Y. W.), and Jie Zhai (J. Z.) performed the literature search and revised the manuscript; Y. H. Q., X. Y. K., X. Y. W., J. Z., Yi Fang (Y. F.), and Jing Wang (J. W.) discussed, revised and edited the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Consent for publication

Not applicable.

Declaration of interest

The authors declare that they have no competing interests.

Availability of data and materials

The data generated or analyzed during this study are included in this article, or if absent are available from the corresponding author upon reasonable request.

Additional information

Funding

This work was partially sponsored by grants from, National Key R&D Program of China [Grant No. 2018YFC1312100], the National Natural Science Foundation of China, no. 81872160 (J. W.), Beijing Municipal Natural Science Foundation (Key program, no. 7191009) (J. W.), Capital Public Health Education, Beijing Science and Technology Program [No. Z161100000116093] (J. W.) and CAMS Initiative for Innovative Medicine [No. 2016-12M-1-007] (J. W.). This article was partially supported by PUMC Youth Fund and the Fundamental Research Funds for the Central Universities [No. 3332015157] (Y. F.), as well as Capital Public Health Education, Beijing Science and Technology Program [No. Z171100000417028] (Y. F.).