Predictive Efficacy of Circulating Tumor Cells in First Drainage Vein Blood from Patients with Colorectal Cancer Liver Metastasis

Abstract

Circulating tumor cells (CTCs) are associated with metastasis. However, the low rate of detection of CTCs in peripheral vein blood (PVB) limits their clinical application. In this study, we observed higher positive rates of CTC in first drainage vein blood (FDVB) relative to peripheral venous blood (p < 0.001). Moreover, the CTC content was related to liver metastasis, T stage, and CA19-9 levels. Our collective data suggest that CTCs in FDVB have good predictive utility for the risk of liver metastasis of colorectal cancer (CRC), in particular, metachronous liver metastasis.

Keywords:

• Circulating tumor cells
• first drainage vein blood
• colorectal cancer
• liver metastasis prediction

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Funding

The present work was financially supported by the Project of the Scientific Research Foundation of Liaoning Province and Wu Jieping Medical Foundation.