The Journey of Resveratrol from Vineyards to Clinics

Abstract

With rising technological advancements, several factors influence the lifestyle of people and stimulate chronic inflammation that severely affects the human body. Chronic inflammation leads to a broad range of physical and pathophysiological distress. For many years, non-steroidal drugs and corticosteroids were most frequently used in treating inflammation and related ailments. However, long-term usage of these drugs aggravates the conditions of chronic diseases and is presented with morbid side effects, especially in old age. Hence, the quest for safe and less toxic anti-inflammatory compounds of high therapeutic potential with least adverse side effects has shifted researchers’ attention to ancient medicinal system. Resveratrol (RSV) − 3,4,5^′ trihydroxystilbene is one such naturally available polyphenolic stilbene derivative obtained from various plant sources. For over 2000 years, these plants have been used in Asian medicinal system for curing inflammation-associated disorders. There is a wealth of in vitro, in vivo and clinical evidence that shows RSV could induce anti-aging health benefits including, anti-cancer, anti-inflammatory, anti-oxidant, phytoesterogenic, and cardio protective properties. However, the issue of rapid elimination of RSV through the metabolic system and its low bio-availability is of paramount importance which is being studied extensively. Therefore, in this article, we scientifically reviewed the molecular targets, biological activities, beneficial and contradicting effects of RSV as evinced by clinical studies for the prevention and treatment of inflammation-mediated chronic disorders.

Keywords:

• Resveratrol
• inflammation
• chronic diseases
• molecular targets
• anti-aging

Declaration of interest

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by BT/556/NE/U-Excel/2016 grant awarded to Ajaikumar B. Kunnumakkara by Department of Biotechnology (DBT), Government of India, and M M Tech programme support by Department of Biotechnology to Department of Bioscience and Bioengineering, IIT Guwahati. This work was also supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) [NRF- 2021R1I1A2060024].