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Abstract
The association between DM and prostate cancer progression remains controversial. Previous studies mainly focused on early stage prostate cancer patients. We aimed to study the association between DM and prostate cancer progression in locally advanced prostate cancer patients. 598 locally advanced prostate cancer patients in a top tertiary hospital in China between 2012 and 2021 were divided into three groups based on the postoperative average HbA1c level. The follow-up time is 46.96 ± 27.07 months. Three hundred and forty-eight (58.2%) were normal glucose, 175 (29.3%) were moderate glucose, and 75 (12.5%) were high glucose. Higher postoperative-average HbA1c was associated with poorer OS, PCSM, and PSA-RFS. We concluded that poorly controlled DM was correlated with poorer OS, PCSM, and PSA-RFS in locally advanced prostate cancer patients.
Author contributions
(I) Conception and design: Cheng Ma, Di Cui and Shujie Xia.
(II) Administrative support: Shujie Xia.
(III) Provision of study materials or patients: Di Cui, Bangmin Han and Shujie Xia.
(IV) Collection and assembly of data: Cheng Ma, Jiahao Zhang and Shiyun Liu.
(V) Data analysis and interpretation: Cheng Ma, Mao Ding and Yingli Gao.
(VI) Manuscript writing: All authors.
(VII) Final approval of manuscript: All authors.
Disclosure statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data availability statement
The datasets generated during the current study are not publicly available due to patients’ privacy, but are available from the corresponding authors on reasonable request.