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Abstract
Shikimic acid (SA) is the drug lead of oseltamivir phosphate (Tamiflu®). The pharmaceutical industry has great demand for SA to match the production of the drug. This article describes the development of an integrated expanded-bed adsorption chromatography (EBAC) system and its application in SA extraction and separation. The hydrodynamic behavior of an expanded-bed ion exchange resin, D293, was investigated to show that D293 resin is able to act as an adsorbent for recovery of SA from Illicium verum. SA was extracted from 8 g of I. verum in 150 mL of deionized water at an expansion ratio of 1.4 via integrated EBAC at 40°C. The SA was then eluted in 200 mL of a 2% NaCl solution. The recovery rate of SA was 96.7% and its purity was 59.6%. Different methods were compared, and the results indicated that the method developed in this article is promising for the recovery of SA from I. verum. The process efficiency of the integrated method was 2.6 times higher than that of the conventional method, while its energy efficiency was about 6 times of that of the conventional method.
| Bo | = | Bodenstein number |
| Rep | = | Reynold number |
| C | = | Concentration of shikimic acid in liquid-phase (mg/mL) |
| C0 | = | Initial concentration of shikimic acid in liquid-phase (mg/mL) |
| Ce | = | Concentration of shikimic acid in liquid-phase at equilibrium (mg/mL) |
| Dax | = | Axial dispersion coefficient (m2/s) |
| H | = | Expanded bed height (cm) |
| H0 | = | Settled bed height (cm) |
| BV | = | Bed volume |
| u | = | Superficial flow velocity (cm/h) |
| ut | = | Terminal flow velocity (cm/h) |
| dp | = | Mean particle diameter (m) |
| g | = | Gravitational acceleration (m/s2) |
| ϵ | = | Voidance of expanded bed |
| ϵ0 | = | Voidance of packed bed |
| ρl | = | Density of liquid phase (kg/m3) |
| ρp | = | Wet density of solid medium (kg/m3) |
| μ | = | Viscosity of liquid phase (Pa·s) |
| tm | = | Mean tracer residence time (min) |
| σm2 | = | Variance of tracer residence time (min2) |
FUNDING
This research was funded by the National Natural Science Foundation of China (No. 21006023, 81273481) and the Fundamental Research Funds for the Central Universities.