The Preparation of Ternary Solid Dispersions of an Herbal Drug via Spray Drying of Liquid Feed

Abstract

The present study aimed the preparation and characterization of ternary solid dispersions by direct spray drying of a liquid suspension containing curcumin, a solubility enhancer and a drying aid. The experiments followed a Box-Behnken design in order to evaluate the influence of temperature, ratio of curcumin: lipidic carrier, and the collodial silicon dioxide content on the characteristics of the microparticulated solid dispersions. The angle of repose, Hausner factor, Carr index, water activity, and solubility were used to characterize solid dispersions. The results show that water activity, Hausner factor, and Carr index varied in an acceptable range for pharmaceutical purposes. The condition that maximizes solubility was determined using an exploratory design based on a surface response analysis and allowed a 3200-fold increase in curcumin solubility. Ternary solid dispersion showed a 90% curcumin release after 10 min during a dissolution test. The results show that the spray drying of a liquid feed is an attractive and promising alternative to obtain enhanced solubility drug ternary solid dispersions.

Keywords:

• Bioavailability
• Curcumin
• Dissolution
• Hard gelatin capsules
• Solubility

ACKNOWLEDGMENTS

The authors gratefully acknowledge the financial support of FAPESP (State of São Paulo Research Foundation), CNPq, and the Gattefossé Co. (France) for supplying Gelucire® 44/14.

Notes

Significant at: *1% and **5%.