Development of a Phytopharmaceutical Intermediate Product via Spray Drying

Abstract

The influence of concentration and incorporation time of different drying excipients on the processing yields and physical properties of Eugenia dysenterica DC spray-dried extracts were investigated following a factorial design. Under the established conditions, the process yield ranged from 57.55 to 89.14%, and in most experiments, the recovered products presented suitable flowability and compressibility, as demonstrated by the Hausner factor, Carr index, and angle of repose. Additionally, in a general way, the parameters related to the dried products' flowability varied over a range acceptable for pharmaceutical purposes. An analysis of variance (ANOVA) proved that both factors and some of their interactions significantly affected most of the investigated responses at different levels. Mannitol proved to be an interesting alternative as an excipient for the drying of herbal extracts, even at low concentrations such as 12.5%. Furthermore, these results imply that the best condition to obtain dry extracts of E. dysenterica with high performance and adequate pharmacotechnical properties involves the lowest concentration and the highest incorporation time of mannitol.

Keywords:

• Factorial design
• Medicinal plant
• Pharmaceutical excipients
• Tableting properties

ACKNOWLEDGMENTS

The authors gratefully acknowledge the financial support of FAPEG (Fundação de Amparo à Pesquisas de Goiás), FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CNPq (PQ-2), and CAPES.

Notes

Significant at: *1%, **5% and ***15%; ns: not significant.

Symbols: ↑ increase; ↓ decrease; ns: not significant.