Spray-Dried Solid Self-Emulsifying Delivery System of Ketoprofen: Development and Its Characterization

Abstract

Ketoprofen is classified as BCS class II drug with low aqueous solubility, short half-life (2–2.5 h), and low oral bioavailability and also causes gastric irritation. The systems intended for oral administration were prepared by using soybean oil, Cremophor EL, and Maisine 35-1 and its adsorption on Aerosil 200. The spray-dried product demonstrated high process yield (52.2–68.3%) with good loading capacity (83.13–93.69%) and significant drug release compared to pure drug. The smooth spherical particles produced had no interaction with the excipients as demonstrated by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). Differential scanning calorimetry (DSC) indicated the complete miscibility of the drug with excipients and X-ray diffraction (XRD) demonstrated the transformation from crystalline to amorphous form.

Keywords:

• Adsorption
• Aerosil 200
• Dissolution
• Emulsification time
• Spray drying

ACKNOWLEDGMENTS

The authors are thankful to the Trustees of MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik, for making the facilities available to us. We are also thankful to Emcure Pharmaceutical, Pune; Gattefosse, France; and BASF, Mumbai, for providing the gift samples.