Regulation of intracellular ATP supply and its application in industrial biotechnology

Abstract

Efficient cell factories are the core of industrial biotechnology. In recent years, synthetic biology develops rapidly, and more and more modified microbial cell factories are employed in industrial biotechnology. ATP plays vital roles in biosynthesis, metabolism regulation, and cellular maintenance. Regulating cellular ATP supply can effectively modify cellular metabolism. This paper presents a review of recent studies on the regulation of the intracellular ATP supply and its application in industrial biotechnology. Detailed strategies for regulating the ATP supply and the resulting impact on bioproduction are introduced. It is observed that regulating the cellular ATP supply can provide great possibilities for making microbial cells into efficient factories. Future perspectives for further understanding the function of ATP are also discussed.

Keywords:

• ATP supply
• metabolic pathways
• electron transport chain
• ATP synthase
• light-driven proton pumps
• ADP supply
• genome reduction

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work received financial support from the National Natural Science Foundation of China [31700075], the Key Research and Development Program of Shandong Province, China [2019JZZY020605], the Natural Science Foundation of the Jiangsu Higher Education Institutions of China [19KJB180001], the Scientific Research Foundation of Changzhou University [ZMF19020298 and ZMF17020115].