Advanced search
Publication Cover
Journal of Biomolecular Structure and Dynamics Volume 15, 1998 - Issue 6
Journal homepage
22
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Quantum Molecular Modeling of the Elastinic Tetrapeptide Val-Pro-Gly-Gly

H. Broch Laboratory of Biophysics GRECFO, University of Nice-Sophia Antipolis, Parc Valrose, 06108, Nice, Cedex 2, France
,
M. Moulabbi Laboratory of Biophysics GRECFO, University of Nice-Sophia Antipolis, Parc Valrose, 06108, Nice, Cedex 2, France
,
D. Vasilescu Laboratory of Biophysics GRECFO, University of Nice-Sophia Antipolis, Parc Valrose, 06108, Nice, Cedex 2, France
&
A. M. Tamburro Department of Chemistry, Universitá della Basilicata, Potenza, Italy
Pages 1073-1091 | Received 27 Oct 1997, Published online: 21 May 2012
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

The free Val-Pro-Gly-Gly tetrapeptide belonging to the Proline-rich sequences of elastin has been studied both theoretically and experimentally. The molecular modelisation was carried out using AM1 and ab initio quantum computations while the conformation in solution was ascertained by circular dichroism spectroscopy performed on the synthesized tetrapeptide. Experimental and theoretical investigations lead to the conclusion that the most probable structure is constituted by a type II β-turn.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Relevance of aggregation properties of tropoelastin to the assembly and structure of elastic fibers.
Source: Elsevier BV
Migration of monocytes in the presence of elastolytic fragments of elastin and in synthetic derivates Structure-activity relationships
Source: Wiley
Circular dichroism, NMR and molecular dynamics studies*
Source: Wiley
Structure of the 3' portion of the bovine elastin gene.
Source: American Chemical Society (ACS)
Conformational Modeling of Elastin Tetrapeptide Boc-Gly-Leu-Gly-Gly-NMe by Molecular Dynamics Simulations with Improvements to the Thermalization Procedure
Source: Informa UK Limited
Bond-optimized ring closure for proline: comparison of conformations and semiempirical energies with small molecule X-ray structures.
Source: Wiley
Quantum and experimental conformational analysis of model molecules related to collagenic structures
Source: Elsevier BV
Crystal structures of repeating peptides of elastin. 2. N-(tert-Butoxycarbonyl)-L-valyl-L-prolylglycylglycine benzyl ester
Source: American Chemical Society (ACS)
An Aggregating Elastin-Like Pentapeptide
Source: Informa UK Limited
Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model
Source: American Chemical Society (ACS)
Peptide models 6. New .beta.-turn conformations from ab initio calculations confirmed by x-ray data of proteins
Source: American Chemical Society (ACS)
Characterization of biologically active domains on elastin: identification of a monoclonal antibody to a cell recognition site.
Source: American Chemical Society (ACS)
Spectroscopic and electron micrographic studies on the repeat tetrapeptide of tropoelastin: (Val-Pro-Gly-Gly)n
Source: Elsevier BV

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.