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Journal of Biomolecular Structure and Dynamics Volume 19, 2002 - Issue 4
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Original Articles

23Na NMR Study of the Interaction between Hyaluronan and the bications Ca++, Mg++ and Cu++

M. Adrian-Scotto Laboratoire de Biophysique
,
M. Guibbolini Laboratoire de Physiologie et Toxicologie Environnementales
,
G. Mallet Laboratoire de Biophysique; I.Re.T I.U.T.de Nice—Côte d'Azur 41 B Napoléon III, 06041, Nice, Cedex, France
,
M. Gaysinski G.U.M.P.A.C. Université de Nice-Sophia Antipolis Parc Valrose, 06108, Nice Cedex 2, France
&
D. Vasilescu Laboratoire de Biophysique
Pages 715-724 | Received 16 Jun 2001, Published online: 15 May 2012
 
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Abstract

The relaxation rate R = πΔν1/2 of the quadrupolar 23Na nucleus was measured at pH ≈ 7 using a 200 MHz NMR spectrometer with a view to observe the interaction between hyaluronan and its natural counterion Na+ and the bications Ca++, Mg++ and Cu++.

An interpretation of our results, by means of the “entropy of fluctuations” concept of Na+, is presented.

We show that Cu++ ions are more effective than Ca++ and Mg++. A possible model of com- plexation of Cu++ in a cage formed by the 1–4 glycosidic bond, the carboxylate side-chain and the acetoamide side-chain is proposed, according to electrostatic potential computations using the ZINDO1 quantum semi empirical method.

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