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Abstract
This work deals with the commonly studied cyclic oligosaccharide and gains importance as it is entered on a drug delivering carbohydrate and provides insight into the oligosaccharide complex–biomolecular interaction. The binding of a flavone, baicalein, to β-cyclodextrin and calf thymus DNA is studied. The binding of baicalein to calf thymus DNA in the presence of β-cyclodextrin is analysed using the UV–vis absorption and fluorescence spectroscopy. The mode of binding and structure of the baicalein–β-cyclodextrin complex are reported. The role of the structure and the stoichiometry of the inclusion complex of baicalein–β-cyclodextrin in its influence on DNA binding are analysed.
Highlights
• This paper deals with the binding of a flavone, baicalein to β-cyclodextrin and/or DNA.
• The inclusion complexation between baicalein and β-cyclodextrin is analysed.
• The stoichiometry and the binding strength of the inclusion complex is reported.
• The role of β-cyclodextrin in tuning the binding of baicalein to DNA is emphasized.
• Spectroscopic and docking analysis are used to articulate the results.
Graphical abstract
The influence of β-cyclodextrin on the binding of baicalein with DNA
Supplementary material
The supplementary material for this paper is available online at http://dx.doi.org/10.1080/07391102.2015.1082148.
Acknowledgements
The authors thank the Department of Science and Technology, Government of India for the financial support through the project SR/FT/CS-062/2009 under the Fast Track Scheme for Young Scientists.
Disclosure statement
No potential conflict of interest was reported by the authors.