Targeting CDK6 in hormone receptor-positive breast cancer: inhibitor discovery for precision oncology through dynamics study

Abstract

CDK6 is a critical protein involved in the regulation of the cell cycle, playing an important role in the progression from the G1 to S phase. In breast cancer, dysregulation of this protein is involved in tumour development and progression, particularly in hormone receptor-positive (HR+) breast cancers. The upregulation of CDK6 have been observed in a subset of breast cancers, leading to uncontrolled progression of the cell cycle and increased proliferation of cells. The purpose of this abstract is to provide an outline of CDK6's role. In breast cancer and the therapeutic strategies targeting CDK6 using specific selected inhibitors. To discover viable therapeutic candidates after competitive inhibition of CDK6 with a small molecular drug complex, high throughput screening and docking studies were used. Further, we carried the compounds based on ADMET properties and prediction of activity spectra for substances analysis. Finally, two different compounds were selected to carry out MD simulations. CDK6-IMPHY002642 and CDK6-IMPHY005260 are the two compounds that were identified. Overall, our results suggest that the CDK6-IMPHY002642 and CDK6-IMPHY005260 complex was relatively stable during the simulation. The compounds that have been found can also be further examined as potential therapeutic possibilities. The combined findings suggest that CDK6, together with their genetic changes, can be investigated in therapeutic interventions for precision oncology, leveraging early diagnostics and target-driven therapy.

Communicated by Ramaswamy H. Sarma

Keywords:

• Cyclin-dependent kinase 6
• high throughput screening
• ADMET properties
• MD simulations
• free energy landscape

Acknowledgement

Sivakumar Annadurai and Shadma Wahab extend their appreciation to the Deanship of Scientific Research at King Khalid University for financial support through Small group Research Project under grant number RGP1/220/44.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

The original contributions presented in the study are included in the article. Further inquiries can be directed to the corresponding author.

Authors’ contributions

All the authors namely Zeenat Khatoon, Mohammad Khalid, Mohammed H. Alqarni, Ahmed I. Foudah, Sivakumar Annadurai, Shadma Wahab and Mohammad Ali Abdullah Almoyad have contributed to conceptualization, investigation, methodology implementation, data analysis and manuscript writing and review.