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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 25, 2008 - Issue 5
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Diurnal Variation of Plasma Brain‐Derived Neurotrophic Factor (BDNF) in Humans: An Analysis of Sex Differences

Armando Piccinni Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
,
MD Donatella Marazziti Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyCorrespondence[email protected]
,
Alessandro Del Debbio Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
,
Carolina Bianchi Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
,
Isabella Roncaglia Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
,
Claudio Mannari Dipartimento di Neuroscienze, University of Pisa, Pisa, Italy
,
Nicola Origlia Institute of Neuroscience, National Research Council, Pisa, Italy
,
Mario Catena Dell'Osso Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
,
Gabriele Massimetti Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
,
Luciano Domenici Institute of Neuroscience, National Research Council, Pisa, Italy; Dipartimento di Scienze e Tecnologie Biomediche, University of L'Aquila, L'Aquila, Italy
&
Liliana Dell'Osso Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
 show all
Pages 819-826 | Received 21 Jan 2008, Accepted 15 May 2008, Published online: 07 Jul 2009
 
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Abstract

Scant information is available on the diurnal variation of peripheral neurotrophic factors, including brain‐derived neurotrophic factor (BDNF), in human beings. We explored plasma and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both sexes. Statistically significant diurnal variation in plasma BDNF level was detected in men, with the peak at 08:00 h and nadir at 22:00 h. At this time, the plasma BDNF concentration of men was significantly lower than that of women (p=.02). However, no diurnal variation was found either in plasma BDNF of women, in either the follicular or luteal phases of the menstrual cycle, or in serum BDNF level in both men and women. These findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex‐related. (Author correspondence: [email protected])

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