Advanced search
Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 35, 2018 - Issue 2
Submit an article Journal homepage
260
Views
11
CrossRef citations to date
0
Altmetric
Short Communication

Influence of a dosing-time on toxicities induced by docetaxel, cisplatin and 5-fluorouracil in patients with oral squamous cell carcinoma; a cross-over pilot study

Yoshiyuki TsuchiyaDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan;Oral and Maxillofacial Surgery, Tochigi Cancer Center, Tochigi, Japan
,
Kentaro UshijimaDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, JapanCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2637-3916
ORCID Icon,
Tadahide NoguchiDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan
,
Naruo OkadaDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan
,
Jun-ichi HayasakaDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan
,
Yoshinori JinbuDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan
,
Hitoshi AndoDepartment of Cellular and Molecular Function Analysis, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan
,
Yoshiyuki MoriDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan
,
Mikio KusamaDepartment of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan;Oral and Maxillofacial Surgery, International University of Health and Welfare Hospital, Tochigi, Japan
&
Akio FujimuraDivision of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi, Japan
 show all
Pages 289-294 | Published online: 16 Nov 2017
 
Sample our Sports and Leisure journals, sign in here to start your FREE access for 14 days

ABSTRACT

Docetaxel, cisplatin plus fluorouracil (DCF) regimen is a useful chemotherapy, but is sometimes withdrawn due to severe adverse effects (AE). In this study, we examined whether the chronotherapy of DCF regimen could reduce the drugs-induced toxicities in clinical practice. Patients with oral squamous cell carcinoma were enrolled. Chemotherapy started at 10:30 (Morning-dosing) or 18:30 (Evening-dosing) for 5 days by a cross-over design. AE were assessed for 14 days after an initiation of each dosing. The grades of nausea, vomiting and neutropenia were smaller during Evening-dosing than during Morning-dosing. These data suggest that the chrono-chemotherapy might provide a merit for reducing the DCF regimen-related severe AE.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 489.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.