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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 35, 2018 - Issue 9
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Short Communications

Chronotype influences response to antidepressant chronotherapeutics in bipolar patients

, , , &
Pages 1319-1325 | Received 13 Nov 2017, Accepted 21 Apr 2018, Published online: 15 May 2018
 

ABSTRACT

Patient diurnal mood fluctuation, sleep characteristics and factors affecting sleep homeostasis predict antidepressant response to the combination of total sleep deprivation and light therapy (TSD + LT). In order to study if chronotype could influence response to TSD+LT, we considered 194 bipolar depressed patients. Severity of depression was rated with Hamilton Depression Rating Scale; perceived mood levels were assessed by a self-administered 10-cm visual analogue scale and chronotype was assessed using the Mornigness-Eveningness Questionnaire.

More than 60% of patients resulted responders to treatment with chronotype influencing the antidepressant response with evening type subjects showing higher response rates.

Declaration of interest

There are no conflicts of interest.

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