ABSTRACT
Introduction
DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population.
Method
DNA methylation of HIF3A was quantified via pyrosequencing.
Result
DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers.
Conclusion
Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.
Acknowledgments
We thank the participants and staff of the Health Examination Program for Residents of Yakumo, Hokkaido, Japan. We also appreciate bioRxiv for accepting this article as a preprint; the preprint doi is 10.1101/2020.11.30.403709.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The datasets analyzed during the current study are available from the corresponding author on reasonable request.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/07435800.2022.2121967