Inflammatory Markers in Thyroid Eye Disease: A Meta-Analysis

ABSTRACT

Thyroid Eye Disease (TED) is an inflammatory autoimmune condition affecting the eyes, often associated with Graves’ disease. Inflammation is important in TED, involving immune cells and orbital tissues. While inflammatory markers have been studied in other diseases, their role in TED is unclear. We included 734 participants from 5 eligible studies investigated associations between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) and TED. Initial analysis found no significant differences in these markers between TED and control groups. However, sensitivity analysis excluding an outlier study revealed significant differences in NLR, PLR, and MLR between groups, suggesting the potential association between these inflammatory markers and TED. More research is needed, but these findings indicate complex TED pathogenesis and that inflammation may offer insights for TED diagnosis and management.

KEYWORDS:

• Meta-analysis
• monocyte-to-lymphocyte ratio
• neutrophil-to-lymphocyte ratio
• platelet-to-lymphocyte ratio
• thyroid eye disease

Disclosure Statement

No potential conflict of interest was reported by the author(s).

Data Availability Statement

The authors confirm that the data supporting the findings of this study are available within the article.

Additional information

Funding

The author(s) reported thereis no funding associated with the work featured in this article.