A Hybrid Selection and Testing Procedure with Curtailment for Comparative Clinical Trials

Abstract

In this paper we use the idea of strong curtailment to define a hybrid selection and testing procedure for finding the best among several experimental Bernoulli populations, provided that it is better than a control Bernoulli population. Our curtailment procedure is based on the fixed-sample-size selection and testing procedure proposed by Thall et al. (1988). Our curtailment procedure reaches the same probability of a correct selection as the original procedure, but requires fewer observations.

Keywords:

• Bernoulli population
• Better efficiency
• Clinical trials
• Correct selection
• Curtailment
• Sample size

Subject Classification:

• 62P10
• 62F07
• 62F03

ACKNOWLEDGMENTS

We wish to express our gratitude to the Editor, Associate Editor, and referee for their helpful suggestions that led to a considerable improvement of this paper.

Notes

Recommended by Nitis Mukhopadhyay