Abstract
Background
As non-specific markers of immune dysregulation, neutrophil–lymphocyte and platelet–lymphocyte ratios (NLR and PLR) have been consistently shown to be increased in major neuropsychiatric disorders. Although this increase seems to be trans-diagnostic, the extent to which its magnitude differs between disorders remains largely unclear.
Aim
The aim of this study was to directly compare the severity of inflammation (as reflected by NLR and PLR) between schizophrenia (Sch), bipolar mania (BD-M), bipolar depression (BD-D), major depressive disorder (MDD) and obsessive compulsive disorder (OCD).
Methods
NLR and PLR were obtained for a total of 417 subjects (91 Sch, 70 BD-D, 37 BD-M, 93 MDD, 37 OCD, and 95 controls) and analyzed for group differences.
Results
Sch, BD-M, BD-D and MDD presented with significantly higher NLR compared with both OCD and HC. NLR in BD-M was significantly higher than all the remaining groups, whereas Sch, BD-D and MDD presented with comparably elevated NLR. Moreover, BD-M, Sch and MDD had significantly higher PLR compared with HC.
Conclusion
These results suggest that the underlying inflammation may be most severe in BD-M, followed by Sch, BD-D and MDD. On the other hand, inflammation may be of negligible intensity in OCD, or at least undetectable by means of NLR or PLR.
Disclosure statement
The authors have no conflicts of interest to declare.
Additional information
Notes on contributors
Necati Serkut Bulut
Necati Serkut Bulut, MD, is a specialist in psychiatry at Marmara University Pendik Training and Research Hospital, Department of Psychiatry, Turkey.
Neşe Yorguner
Neşe Yorguner, MD, is assistant professor at Marmara University Pendik Training and Research Hospital, Department of Psychiatry, Turkey.
Gresa Çarkaxhiu Bulut
Gresa Çarkaxhiu Bulut, MD, is assistant professor at Maltepe University Medical School, Department of Child and Adolescent Psychiatry, Turkey.