ABSTRACT
Clinical Relevance
Vitamin D has regulatory effects on non-skeletal tissues including neurons. The contrast sensitivity function occurs as a result of interaction between retinal neurons.
Background
The association between plasma vitamin D deficiency and contrast sensitivity function was investigated.
Methods
Forty-one eyes of 41 subjects with vitamin D deficiency with plasma vitamin D level <20 ng/mL (Group 1), and 30 eyes of 30 subjects without vitamin D deficiency with plasma vitamin D level ≥20 ng/mL (Group 2), were included in this prospective study. OPTEC 6500 was used to measure the contrast sensitivity function at all spatial frequencies involving 1.5 cpd, 3 cpd, 6 cpd, 12cpd, and 18 cpd. The average and sectorial retinal nerve fibre layer thickness, the average and minimum ganglion cell-inner plexiform thickness and tear meniscus height were measured by using optical coherence tomography.
Results
A significant difference was present between Group 1 and Group 2 regarding the plasma vitamin D level (12.4 ± 4.7 ng/mL in Group 1 versus 27.1 ± 6.7 ng/mL in Group 2 p < 0.001). All spatial frequencies of contrast sensitivity function were significantly greater in Group 2 than those in Group 1, as follows: 45 ± 22.6 in Group 1 versus 57.5 ± 20.9 in Group 2, p = 0.08 in 1.5cpd; 71.3 ± 31.3 in Group 1 versus 91.8 ± 27.8 in Group 2, p = 0.001 in 3cpd; 77.9 ± 39.9 in Group 1 versus 100.4 ± 38.4 in Group 2, p = 0.013 in 6cpd; 32 ± 17.5 in Group 1 versus 48.8 ± 25.2 in Group 2, p = 0.002 in 12cpd; and 12.1 ± 5 in Group 1 versus 17.5 ± 9.5 in Group 2, p = 0.001 in 18cpd. However, there were no significant difference between two groups in terms of retinal fibre layer thicknesses, ganglion cell-inner plexiform layer thicknesses, and tear meniscus height.
Conclusion
Vitamin D deficiency can lead to a decrease in contrast sensitivity function that is an indicator of visual quality. This may be an underlying reason for certain visual complaints.
Disclosure statement
None of the authors have any potential conflict of interest to disclose.
This study was approved by the following research ethic committee: Canakkale Onsekiz Mart University Ethics Committee (Decision Date: 13/03/2019 Decision Number: 2019-06).